About Bifurcational Parametric Simplification

An entropy-like index of bifurcational robustness for metabolic systems.

Natural and synthetic metabolic pathways need to retain stability when faced against random changes in gene expression levels and kinetic parameters. In the presence of large parameter changes, a robust system should specifically avoid moving to an unstable region, an event that would dramatically change system behavior. Here we present an entropy-like index, denoted as S, for quantifying the b...

Floating stenting: yet another technique of bifurcational stenting?

If you surf the net to check tctmd.com or europcr. com, or the many other competing web sites, looking for talks on bifurcations, you will notice that they always start showing a tree branch or 2 rivers slowly merging and always finish saying that you have to use one stent only and cover the side-branch origin. Hopefully, next year they will start with bull horns instead, a Spanish national obs...

Inference about clustering and parametric assumptions in covariance matrix estimation

Selecting an estimator for the covariance matrix of a regression’s parameter estimates is an important step in hypothesis testing. From less robust to more robust, the available choices include: Eicker/White heteroskedasticity-robust standard errors, cluster-robust standard errors, and multi-way cluster-robust standard errors. The rationale for using a less robust covariance matrix estimator is...

Symbolic Techniques for Parametric Reasoning about Counter and Clock Systems

We address the problem of automatic analysis of parametric counter and clock automata. We propose a semi-algorithmic approach based on using (1) expressive symbolic representation structures called Parametric DBM's, and (2) accurate extrapolation techniques allowing to speed up the reachability analysis and help its termination. The techniques we propose consist in guessing automatically the ee...

Over-Simplification